## III. |
## Online Tool for Calculating the Parameters of Loop Entropy Factor Approximation |

The large-scale nature of computing the human genomic melting map required that very large loops (melting bubbles) were properly accounted for by the algorithm. This was achieved by having sufficiently many terms (exponentials) in the Fixman-Freire approximation of the loop entropy factor.

We here provide an online tool for calculating the parameter values for all the terms in the loop entropy approximation for arbitrary sequence length and loop exponent: